![]() ![]() However, some individuals such as high altitude dwellers cope well with an increased hematocrit level. I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.Severe elevation of red blood cell number is often associated with hypertension and thromboembolism resulting in severe cardiovascular complications. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Patients or caregivers provided written informed consent for additional blood sampling and viscosity measurements. The local institutional review board of Seoul National University Bundang Hospital (Republic of Korea) approved this study. The details of the IRB/oversight body that provided approval or exemption for the research described are given below: I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. The results were partly supported by "Regional Innovation Strategy (RIS)" through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE) (2021RIS-004). This work was partly supported by the Technology Development Program (S3094866) funded by the Ministry of SMEs and Startups (MSS, Korea). This study is a prospective observational study and not registered to the ACMJE-approved registry. ![]() JS Oh holds the patent for the ARS-MEDI parallel plate viscometer used in this study and is the CEO of the Rheology Solutions Co., which manufactured the viscometer. At an oscillatory frequency of 10 Hz, blood viscosity differed significantly between the ischemic stroke (24.2 4.9 cP) and stroke mimic groups (17.8 6.5 cP, P Conclusion: Patients with ischemic stroke exhibit increases in whole blood viscosity when admitted within 24 h of last known well time, suggesting that blood viscosity measurements can aid in differentiating ischemic stroke from other diseases. Results: Among 112 enrolled patients, blood viscosity measurements were accomplished within 2.4 1.3 min of vessel puncture. Blood viscosity results were compared among patients with stroke mimics, ischemic stroke, and hemorrhagic stroke. Blood viscosity was measured as the reactive torque generated at three different oscillatory frequencies (1, 5, and 10 Hz). Point-of-care testing was used to obtain blood viscosity measurements before intravenous fluid infusion. We aimed to investigate the effect of blood viscosity on stroke occurrence and the clinical utility of blood viscosity measurements obtained immediately upon hospital arrival.Methods: Patients with suspected stroke visiting the hospital within 24 h of the last known well time were enrolled. However, there is limited evidence to date regarding the role of high blood viscosity in acute thrombogenic events. Background: Changes in blood viscosity can influence the shear stress level at the vessel wall. ![]()
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